Mississippi plantation mistress Amanda Satterfield loses her daughter to cholera after her husband refuses to treat her for what he considers to be a "slave disease". Insane with grief, Amanda takes a newborn slave child as her own and names her Granada, much to the outrage of her husband and the amusement of their white neighbors. Troubled by his wife's disturbing mental state and concerned about a mysterious plague sweeping through his slave population, Master Satterfield purchases Polly Shine, a slave reputed to be a healer. But Polly's sharp tongue and troubling predictions cause unrest across the plantation. Complicating matters further, Polly recognizes "the gift" in Granada, the mistress's pet, and a domestic battle of wills ensues.